Millennium Pain Center Leaders in Pain Control, Research, Education and Advocacy.
  • Research

    Millennium Pain Center is a State-of-the-Art Center of Excellence. Our mission is early phase involvement in the development of clinical and basic research medications and treatment modalities. We are dedicated to providing our patients with a superior standard of care. We have an experienced research staff who follow Good Clinical Practices to ensure the subject’s safety and well being are always our first priority.


    Drs. Benyamin and Vallejo has authored more than 110 manuscripts published in peer reviewed indexed medical journals. Additionally they authored more than 12 book chapters. They serve on the editorial board of multiple national and international peer reviewed journals such as: Pain Physician, Clinical Journal of Pain, Journal of Opioid Management, and Pain Practice, Regional Anesthesia and Pain Management. 


    Drs. Benyamin and Vallejo are the primary investigator and sub investigator of more than 100 clinical trials done at Millennium pain Center.



    Clinical  Research:


    Contact one of our Clinical Research Coordinators






    Katie Mahnke, Clinical Research Coordinator

    2406 E. Empire St.

    Bloomington, IL 61701

    (309) 220-9852

    Meet our Second Clinical Research Coordinator, Echo





    Echo Cundiff, Clinical Research Coordinator

    2406 E. Empire St.

    Bloomington, IL 61701

    (309) 220-9852

    Stephanie is a dedicated member of our Research Coordination Team





    Stephanie Wolfe, Clinical Research Coordinator

    2406 E. Empire St.

    Bloomington, IL 61701

    (309) 220-9852 





    For Current studies being conducted click HERE




    Pre-Clinical  Research:


    Millennium Pain Center supports a pre-clinical research laboratory located on the campus of Illinois State University, Normal, IL. The research primarily focuses on determining the mechanism by which these pain therapies reduce or eliminate pain sensation. Currently research is being actively pursued in the areas of electrical spinal neuromodulation and pain treatment alternatives using pulsed-radiofrequency.



    DAVID L. CEDEÑO, Ph.D. Research Lab Director and Associate Professor


    Dr. David L. Cedeño is the Director of Basic Research at the Millennium Pain Center (Bloomington, IL) and an Associate Professor of Chemistry at Illinois State University (Normal, IL). He got his Diploma in Chemistry (B.S. equivalent) at Universidad del Valle and worked as a research and development chemist at Colgate-Palmolive and Lloreda Soaps and Glycerine in Cali, Colombia. He earned his doctorate from Baylor University in 1999 and was a postdoctoral fellow at Northwestern University from 1999 to 2001. He moved to Illinois State University in2001 as an assistant professor and earned tenure and promotion to associate professor in 2007. He has been associated with the Millennium Pain Center since 2012. Dr. Cedeño has authored/coauthored 33 peer-reviewed publications, two patent applications and 57 research and education presentations. Dr. Cedeño’s academic efforts at Illinois State University have been recognized with a Research Initiative Award, the John Dorsey Award for Outstanding Teacher, and the College of Arts and Sciences Awards for Outstanding Teaching and Outstanding Service. His research interests include the development of novel diagnostic and therapeutic agents for chronic pain, the development of photodynamic treatment drugs for cutaneous leishmaniasis, and the development of choline inhibitors for the treatment of visceral leishmaniasis.





    Senior Scientist and Adjunct Research Professor at IWUCynthia Cass, Ph.D.


    Dr. Cynthia L. Cass is the Senior Scientist of Basic Research at Millennium Pain Center and an Adjunct Research Professor at Illinois Wesleyan University. Cynthia got her Bachelor of Arts in Biology at the University of California, Santa Cruz, where her interest in molecular biology was sparked. She worked as a research technician in cancer research at the Veterans Administration Medical Center in Sepulveda, California, before earning her Doctorate of Philosophy in Microbiology as part of the Cell and Molecular Biology program from the University of Virginia. She then moved to Spokane, Washington to raise young children, and take advantage of the area’s outdoor opportunities. Cynthia moved to Illinois State University in 2005 and worked as a postdoctoral fellow on a human parasite, and then as a senior research scientist in plant molecular genetics at Illinois State as part of the Great Lakes Bioenergy Research Center beginning in 2008. Cynthia has been associated with the Millennium Pain Center since 2016, where she is working to elucidate the molecular events associated with neuropathic pain and therapy. Cynthia has authored/coauthored 14 peer-reviewed publications and has enjoyed mentoring and teaching numerous PhD, Master’s and undergraduate students.









    COURTNEY KELLEY, B.S. Research Team member and research affiliate at IWU


    Courtney Kelley received her Bachelor of Science in Biology from Illinois State University in 2009 where she took advantage of opportunities to conduct undergraduate research and found her passion for science. Prior to her current role, Courtney worked in industrial lab in Decatur, IL. She has been a part of the basic science research team at Millennium Pain Center since 2012, investigating the mechanisms behind chronic neuropathic pain and therapy.

    Courtney’s emphasis inside the lab also includes education. As a research affiliate at Illinois Wesleyan University and former adjunct faculty member of Illinois State University, she has worked with many students; mentoring and assisting with student research projects, and providing a hands-on experience in science and medicine.

    Courtney is currently pursuing her Master of Science in Biotechnology with a specialization in Bioinformatics through the University of Maryland University College, where she is maintaining excellent academic performance.







    Basic  Science  Research:


    The Basic Science research program is in collaboration with local universities such as: Illinois State University, Illinois Weslyan, University of Illinois at Chicago with the main goal of seeking new and novel treatments for common painful conditions. 


    Our basic science research group is funded by the Millennium Pain Center, La Marató de TV3 Foundation, and Boston Scientific.